Iso-Osmolar Iodixanol Induces Less Increase in Circulating Endothelial Microparticles In Vivo and Less Endothelial Apoptosis In Vitro Compared with Low-Osmolar Iohexol

The relative renal safety of iodixanol compared with low-osmolar contrast media.

A meta-analysis of the renal safety of isosmolar iodixanol compared with low-osmolar contrast media.

OBJECTIVES We sought to compare the nephrotoxicity of isosmolar contrast medium (IOCM) iodixanol with low-osmolar contrast media (LOCM) and to identify predictors of contrast-induced nephropathy (CIN). BACKGROUND Contrast-induced nephropathy is a serious complication of diagnostic and interventional procedures. METHODS Pooled individual patient data (n = 2,727) from 16 double-blind, randomi...

Iso-Osmolar versus Low-Osmolar Contrast Media in Reducing Contrast Induced Nephropathy in Patient with Renal Impairment Undergoing Coronary Angiography

Renal failure in 57 925 patients undergoing coronary procedures using iso-osmolar or low-osmolar contrast media.

We compared the Swedish Coronary Angiography and Angioplasty Registry with the Swedish 'Hospital Discharge Register' to assess contrast media (CM)-induced renal failure. Hospitals used only one type CM. From 2000 to 2003, iodixanol (iso-osmolar) was used in 45 485 patients, ioxaglate (low osmolar) in 12 440 subjects. To include the earlier used CM iohexol (low osmolar), analysis extended back t...

C-reactive protein induces release of both endothelial microparticles and circulating endothelial cells in vitro and in vivo: further evidence of endothelial dysfunction.

BACKGROUND Inflammation is pivotal in atherosclerosis. A key early event in atherosclerosis is endothelial dysfunction. C-reactive protein (CRP), the prototypic marker of inflammation in humans, is a risk marker for cardiovascular disease, and there is mounting evidence to support its role in atherothrombosis. CRP has been shown to promote endothelial dysfunction both in vitro and in vivo. Emer...